Tissue Biobank at Karolinska Hospital

Name of biobank:

Tissue biobank at Karolinska Hospital

General Information:

Collection of tissue removed during surgical operations. The bank started prospectively in 1986 for tissue from thyroid, parathyroid and abdominal endocrine tumors. From 2002 also tissue from breast tumors urologic tumors, melanoma and GI tumors are included. Main aim is to use tissue for molecular biology

Responsible organisation:

Research committee at Karolinska Hospital

Responsible principle scientist:

Bertil Hamberger

Rules for acess:

Application to principal scientist. Group involved in collecting samples decides concerning access

Biobank content:

• About 3500 tissue specimen of thyroid parathyroid and abdominal endocrine organs collected from 1986-2003.
   
• Since 2002 also tissue specimen from breast cancer, urologic tissue melanoma.
   
• All tissue frozen fresh within 15 min in liquid nitrogen and stored at –70 C.
   

Attached database:

Yes A new database developed and since July 2002 in routine use. The aim is primarily to help to handle tissue. It contains patient identification, pathology identification, ethical approval, normal or pathological tissue, pathology coding number of specimen and where in the freezer they are located. In addition the database handles any withdrawal from the biobank.

Up to five selected publications:

• Valimaki S, Forsberg L, Farnebo LO, Larsson C
  Distinct target regions for chromosome 1p deletions in parathyroid adenomas and carcinomas.
  Int J Oncol. 2002 Oct;21(4):727-35.
   
• Kjellman P, Wallin G, Hoog A, Auer G, Larsson C, Zedenius J.
  MIB-1 index in thyroid tumors: a predictor of the clinical course in papillary thyroid carcinoma.
  Thyroid. 2003 Apr;13(4):371-80.
   
• Frisk T, Foukakis T, Dwight T, Lundberg J, Hoog A, Wallin G, Eng C, Zedenius J, Larsson C.
  Silencing of the PTEN tumor-suppressor gene in anaplastic thyroid cancer.
  Genes Chromosomes Cancer. 2002 Sep;35(1):74-80.
   
• Kjellman P, Lagercrantz S, Hoog A, Wallin G, Larsson C, Zedenius J.
  Gain of 1q and loss of 9q21.3-q32 are associated with a less favorable prognosis in papillary thyroid carcinoma.
  Genes Chromosomes Cancer. 2001 Sep;32(1):43-9.
   
• Enberg U, Farnebo LO, Wedell A, Grondal S, Thoren M, Grimelius L, Kjellman M, Backdahl M, Hamberger B.
  In vitro release of aldosterone and cortisol in human adrenal adenomas correlates to mRNA expression of steroidogenic enzymes for genes CYP11B2 and CYP17.
  World J Surg. 2001 Jul;25(7):957-66.
   

Role in The National Biobanking Programme:

Development of database for use in hospital to take care of operative tissue. In addition logistics for running smoothly the whole chain from patient information to banking access.