Swedish Institute for Infectious Disease Control Biobank

Name of biobank:

Swedish Institute for Infectious Disease Control Biobank

General Information:

The Swedish Institute for Infectious Disease Control (SIIDC) has performed a series of population-based, nationwide investigations on the immunity against infections in the Swedish population. In 1968, 3000 subjects were samples, in 1977/78 1845 subjects, in 199-91 4800 subjects and in 1997 2400 subjects were sampled. The samples have been analysed for the age-specific population immunity of e.g. polio, parotitis, measles, rubell, diphtheria and tetanus.

SIIDC has also during decades served as a reference laboratory for many microbiological analyses. As a part of the quality control and documentation system, part of the samples that have been analysed have been stored at minus 20 C. Samples have been stored since 1957 and complete series of samples are stored since 1977.

Responsible organisation:

Swedish Institute for Infectious Disease Control

Responsible principle scientist:

The biobank is currently being reorganized. Professor Joakim Dillner is currently the responsible project leader of the reorganisation. The administrative responsibility of the biobank rests with the head of the SIIDC, Ragnar Norrby.

Rules for acess:

An application should be sent to the Steering Group. Please contact the quality assurance manager Lena Lindberg for instructions and forms.

Biobank content:

1. The biobank contains at least 900.000 biological samples. The biobank is currently being computerized and the information on the samples have as yet been transferred from paper documentation to computerized files only for about 629.000 samples. Research studies can in many instances only be performed on the registered part of the biobank, but for certain specific research questions or for individual clinical diagnosis also the part of the biobank that is documented only on paper is accessible.
    
2. Most samples are serum samples and have had an original volume of one milliliter.
    
3. The storage temperature is at minus 20 degrees.
    

Attached database:

Yes
The clinical database contains the clinical information provided on the referral sheet as well as the results of the requested virus analyses. Registry linkages based on the personal identification number have not been made as yet.

Up to five selected publications:

• Bottiger M, Gustavsson O, Svensson A.
  Immunity to tetanus, diphtheria and poliomyelitis in the adult population of Sweden in 1991.
  Int J Epidemiol. 1998 Oct;27(5):916-25.
   
• Broliden K, Abreu ER, Arneborn M, Bottiger M.
  Immunity to mumps before and after MMR vaccination at 12 years of age in the first generation offered the two-dose immunization programme.
  Vaccine. 1998 Jan-Feb;16(2-3):323-7.
   
• Christenson B, Bottiger M, Grillner L.
  The prevalence of hepatitis B in Sweden; a statistical serosurvey of 3381 Swedish inhabitants.
  Epidemiol Infect. 1997 Oct;119(2):221-5.
   
• Bottiger M, Christenson B, Grillner L.
  Hepatitis A immunity in the Swedish population. A study of the prevalence of markers in the Swedish population.
  Scand J Infect Dis. 1997;29(2):99-102.
   
• Bottiger M, Gustavsson O, Svensson A.
  Need for supplementary vaccination against diphtheria. Protection is insufficient, especially among women over 40 years of age
  Lakartidningen. 1994;91(47):4357-61.
   

Role in The National Biobanking Programme:

Contribution to the National Biobanking program: The SIIDC biobank received already in 2000 a 250.000 SEK start up-grant for exploration of the biobank from the WCN biobanking programme. Following definitions of the necessary tasks, funds for reorganization of the biobank of (3.2 million SEK) were requested and approved by the Swedish government, Dept. of Health and Welfare. The SIIDC biobank participates in the national networking towards improved quality assurance, "Good Biobanking Practise".