Malmö Diet and Cancer

Name of biobank:

Malmö Diet and Cancer biobank

General Information:

Prospective observational population-based study with a baseline examination 1991-1996 (n = 28098) And follow ups of mortality and morbidity by means of registries. Main focus on cancer and cardiovascular disease.

Responsible organisation:

Lunds Universitet

Responsible principle scientist:

Göran Berglund

Rules for acess:

A document describing the rules and guidelines for an access application will be added shortly. For the time being contact Göran Berglund.

Biobank content:

Each blood donor to the bank contributes a 40-ml sample, and 30 ml of the blood sample is committed to blood fractionation while the other 10 ml is used to prepare a serum sample from this amount of blood the following samples for each subject are stored in the bank:

• Erythrocytes 2 x 1.0 ml stored at -80°C.
   
• Granulocytes 1 x 1.0 ml stored at -80°C.
   
• Mononuclear leucocytes 3 x 1.0 ml stored at -140°C.
   
• Plasma 2 x 1.8 ml stored at -80°C.
   
• Serum 2 x 1.0 ml stored at -80°C.
   

Attached database:

Yes

Variables in database:

• Baseline examination
   
  • Questionnaire
     
    • Heredity
    • Occupation
    • Social-economy
    • Previous diseases
    • Medication, non-prescript drugs
    • Diet- a combination of 1 week menu book and a food frequency questionnaire
       
  • Measurements
     
    • BP, carotid ultrasound imaging
    • Anthropometry
       
• Follow-up
   
  • Five year follow-ip
     
  • BCAPS - screen
     
  • HOMA cohort
     
  • PLQ cohort
     
• End-points
   
  • Mortality
     
  • Cancer events
     
  • Cardiovascular events
     
  • Other morbidity
     

Up to five selected publications:

• Pero RW, Olsson A, Berglund G, Janzon L, Larsson SA, Elmstahl S. The Malmo biological bank. J Intern Med. 1993 Jan;233(1):63-7.
   
• Pero RW, Olsson A, Bryngelsson C, von Schantz T, Simanaitis M, Sternby NH, Larsson SA, Elmstahl S, Janzon L, Berglund G. Feasibility and quality of biological banking of human normal and tumor tissue specimens as sources of DNA for the Malmo Diet and Cancer Study. Cancer Epidemiol Biomarkers Prev. 1998 Sep;7(9):809-12.
   
• Pero RW, Olsson A, Bryngelsson C, Carlsson S, Janzon L, Berglund G, Elmstahl S. Quality control program for storage of biologically banked blood specimens in the Malmo Diet and Cancer Study. Cancer Epidemiol Biomarkers Prev. 1998 Sep;7(9):803-8
   

Role in The National Biobanking Programme:

1. Coordinates the work package on optimisation and quality control of DNA extraction (WP 4.1) methods from whole blood, serum, paraffin blocks etc.
    
2. Performs an improvement on the biobank infrastructure by a) systematic DNA extraction and arraying of all samples b)implements a formal quality control system c) provides data on usefulness of samples such as endpoints and quality documentation to the National Biobanking programme joint database.
    
3. Delivers samples for epidemiological research. A complete listing of samples delivered during 2002 will be posted here soon.