The Cardiovascular Risk of 60-Year-Old People

Name of biobank:

The cardiovascular risk of 60-year-old people - an epidemiological cohort study on men and women, born 1937 and 1938 in Stockholm County.

General Information:

To evaluate the predictive power of both new and old cardiovascular risk factors for the occurence of different cardiovascular diseases in men and women after the age of 60, a cohort of 4,260 60-year-old men and women, born 1937 and 1938 within Stockholm County, was established 1997-1998. At baseline, the 60-year-old people were subjected to a thorough health check-up, including characterization of various environmental exposure and biochemical/genetic risk factors. A large biobank was established, containing serum. The cohort will be followed for the currency of cardiovascular end-points, including diabetes mellitus. Annual matchings with several national cardiovascular registers will take place.

Responsible organisation:

Karolinska Institute.

Responsible principle scientist:

Professor Ulf de Faire

Rules for acess:

Rules and guidelines for access applications will be added later on. For the time being, contact Ulf de Faire.

Biobank content:

Each blood donor has contributed to biochemical analyses at baseline (see Biochemical Variables at Baselines). Serum, EDTA-plasma, citrate plasma, and whole blood have been stored at -80 C in freezers both at Karolinska Hospital and Karolinska Institutet.
Plasma 12x0.5 ml, citrate plasma 10x0.5 ml, serum 16x0.5 ml.
Whole blood 3-4x4.5 ml.
DNA has been extracted on parts of the material (1077 male subjects. It is intended to extract DNA from all subjects.)

Attached database:

Yes

Variables in database:

Baseline examination.
Questionnaire, heredity.
Occupation.
Social economy.
Life events, socioeconomic stress.
Previous diseases.
Medication, non-prescript drugs.
Diet, alcohol, exercise.
Measurements:
- BP height, weight, BMI, W/H ratio, resting ECD.
Endpoints:
- Annual matchings with cardiovascular registers as regards MI, other CHD, stroke, CABG, PCI, death.
Biochemical variables at baseline:
- Hb, CRP, S-urate, gamma-GT, S-cholesterol, S-triglycerides, HDL cholesterol, LDL cholesterol, apolipoprotein A1, apolipoprotein B, Lp(a), blood glucose, S-insulin.

Up to five selected publications:

Rosell MS, Hellenius ML, de Faire UH, Johansson GK.
Associations between diet and the metabolic syndrome vary with the validity of dietary intake data.
Am J Clin Nutr 2003;78:84-90.
Lindgren P, Fahlstadius P, Hellenius ML, Jonsson B, de Faire U.
Cost-effectiveness of primary prevention of coronary heart disease through risk factor intervention in 60-year-old men from the county of Stockholm-a stochastic model of exercise and dietary advice.
Prev Med 2003;36:403-409.
Rosell M, de Faire U, Hellenius ML.
Low prevalence of the metabolic syndrome in wine drinkers - is it the alcohol beverage or the lifestyle?
Eur J Clin Nutr 2003;57:227-234.